Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS
Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS
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United States: Elsevier Inc
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English
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United States: Elsevier Inc
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Adeno-associated virus (AAV) is the most common vector for clinical gene therapy of the CNS. This popularity originates from a high safety record and the longevity of transgene expression in neurons. Nevertheless, clinical efficacy for CNS indications is lacking, and one reason for this is the relatively limited spread and transduction efficacy in...
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Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS
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TN_cdi_doaj_primary_oai_doaj_org_article_6d0d371fda0549eea1c15d7cb44b1c23
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d0d371fda0549eea1c15d7cb44b1c23
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ISSN
2162-2531
E-ISSN
2162-2531
DOI
10.1016/j.omtn.2017.06.011
