Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to...
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Since their discovery as drivers of proliferation, cyclin-dependent kinases (CDKs) have been considered therapeutic targets. Small molecule inhibitors of CDK4/6 are used and tested in clinical trials to treat multiple cancer types. Despite their clinical importance, little is known about how CDK4/6 inhibitors affect the stability of CDK4/6 complexe...
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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
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TN_cdi_doaj_primary_oai_doaj_org_article_6d14f142aabc4361a0362428e11c38f1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d14f142aabc4361a0362428e11c38f1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23612-z
