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Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in...

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d41288a5b94486dae4ca55aef26eb14

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

About this item

Full title

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Publisher

England: BioMed Central Ltd

Journal title

Molecular brain, 2012-10, Vol.5 (1), p.35-35, Article 35

Language

English

Formats

Publication information

Publisher

England: BioMed Central Ltd

More information

Scope and Contents

Contents

Parkinson's disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form of PD, PARK2, is caused by mutations in the parkin gene. parkin-knockout mouse models show some abnormalities, but they do not fully recapitulate the pathophysiology of human PARK2.<...

Alternative Titles

Full title

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_6d41288a5b94486dae4ca55aef26eb14

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d41288a5b94486dae4ca55aef26eb14

Other Identifiers

ISSN

1756-6606

E-ISSN

1756-6606

DOI

10.1186/1756-6606-5-35

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