Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Tumor growth relies on efficient DNA repair to mitigate the detrimental impact of DNA damage associated with excessive cell division. Modulating repair factor function, thus, provides a promising strategy to manipulate malignant growth. Here, we identify the ubiquitin-specific protease USP21 as a positive regulator of BRCA2, a key mediator of DNA r...
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Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
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TN_cdi_doaj_primary_oai_doaj_org_article_6d416f5188234f9fa281c79b9c130b8a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d416f5188234f9fa281c79b9c130b8a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00206-2
