Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglut...
Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation
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Author / Creator
Zhang, Ning , Sun, Linmao , Zhou, Shuo , Ji, Changyong , Cui, Tianming , Chu, Qi , Ye, Jiareng , Liang, Shuhang , Ma, Kun , Liu, Yufeng , Li, Xianying , Guo, Xinyu , Zhang, Weizhi , Gu, Xuetian , Cheng, Cheng , Zha, Qingrui , Tao, Shengwei , Zhang, Yunguang , Chu, Junhui , Wu, Chenghui , Zhang, Yuchen , Wang, Jiabei , Liu, Yao and Liu, Lianxin
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Gemcitabine combined with cisplatin is the first-line chemotherapy for advanced cholangiocarcinoma, but drug resistance remains a challenge, leading to unsatisfactory therapeutic effect. Here, we elucidate the possibility of chemotherapy regimens sensitized by inhibiting succinylation in patients with cholangiocarcinoma from the perspective of post...
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Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation
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TN_cdi_doaj_primary_oai_doaj_org_article_6d5a41e120304dfb8e9cde693e11f63b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d5a41e120304dfb8e9cde693e11f63b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58429-7
