A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis
A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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RMRP
encodes a non-coding RNA forming the core of the RNase MRP ribonucleoprotein complex. Mutations cause Cartilage Hair Hypoplasia (CHH), characterized by skeletal abnormalities and impaired T cell activation. Yeast RNase MRP cleaves a specific site in the pre-ribosomal RNA (pre-rRNA) during ribosome synthesis. CRISPR-mediated disruption of
Alternative Titles
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A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis
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TN_cdi_doaj_primary_oai_doaj_org_article_6d72bec339554c86a887521d12ef03cb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d72bec339554c86a887521d12ef03cb
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-28295-8
