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22 Humanized NOG-EXL mice exhibit improved overall survival and less severe myeloid cell activation...

22 Humanized NOG-EXL mice exhibit improved overall survival and less severe myeloid cell activation...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d8b03048d2f4291923672da843e7972

22 Humanized NOG-EXL mice exhibit improved overall survival and less severe myeloid cell activation relative to humanized NSG-SGM3 mice

About this item

Full title

22 Humanized NOG-EXL mice exhibit improved overall survival and less severe myeloid cell activation relative to humanized NSG-SGM3 mice

Publisher

London: BMJ Publishing Group Ltd

Journal title

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A24-A24

Language

English

Formats

Publication information

Publisher

London: BMJ Publishing Group Ltd

More information

Scope and Contents

Contents

BackgroundEngraftment efficiency of human immune cell lineages in super immunodeficient mice varies, and numerous strains have been developed to improve reconstitution of humanized immune system mice. NSG-SGM3 and NOG-EXL mice combine severe immunodeficiency with transgenic expression of human myeloid stimulatory cytokines, resulting in improved ex...

Alternative Titles

Full title

22 Humanized NOG-EXL mice exhibit improved overall survival and less severe myeloid cell activation relative to humanized NSG-SGM3 mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_6d8b03048d2f4291923672da843e7972

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6d8b03048d2f4291923672da843e7972

Other Identifiers

E-ISSN

2051-1426

DOI

10.1136/jitc-2023-SITC2023.0022

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