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Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation...

Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6db17430acc04ff2b78194f3ababa535

Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster

About this item

Full title

Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2024-07, Vol.14 (1), p.16567-12, Article 16567

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Serine proteases are important regulators of airway epithelial homeostasis. Altered serum or cellular levels of two serpins,
Scca1
and
Spink5
, have been described for airway diseases but their function beyond antiproteolytic activity is insufficiently understood. To close this gap, we generated fly lines with overexpression or knockdow...

Alternative Titles

Full title

Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_6db17430acc04ff2b78194f3ababa535

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6db17430acc04ff2b78194f3ababa535

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-024-66752-0

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