Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation...
Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Serine proteases are important regulators of airway epithelial homeostasis. Altered serum or cellular levels of two serpins,
Scca1
and
Spink5
, have been described for airway diseases but their function beyond antiproteolytic activity is insufficiently understood. To close this gap, we generated fly lines with overexpression or knockdow...
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Full title
Airway specific deregulation of asthma-related serpins impairs tracheal architecture and oxygenation in D. melanogaster
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TN_cdi_doaj_primary_oai_doaj_org_article_6db17430acc04ff2b78194f3ababa535
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6db17430acc04ff2b78194f3ababa535
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-66752-0