The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic...
The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk
About this item
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Author / Creator
Valdecantos, M. Pilar , Ruiz, Laura , Folgueira, Cintia , Rada, Patricia , Gomez-Santos, Beatriz , Solas, Maite , Hitos, Ana B. , Field, Joss , Francisco, Vera , Escalona-Garrido, Carmen , Zagmutt, Sebastián , Calderon-Dominguez, María , Mera, Paula , Garcia-Martinez, Irma , Maymó-Masip, Elsa , Grajales, Diana , Alen, Rosa , Mora, Alfonso , Sáinz, Neira , Vides-Urrestarazu, Irene , Vilarrasa, Nuria , Arbones-Mainar, José M. , Zaragoza, Carlos , Moreno-Aliaga, María J. , Aspichueta, Patricia , Fernández-Veledo, Sonia , Vendrell, Joan , Serra, Dolors , Herrero, Laura , Schreiber, Renate , Zechner, Rudolf , Sabio, Guadalupe , Hornigold, David , Rondinone, Cristina M. , Jermutus, Lutz , Grimsby, Joseph and Valverde, Ángela M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Bariatric surgery is effective for the treatment and remission of obesity and type 2 diabetes, but pharmacological approaches which exert similar metabolic adaptations are needed to avoid post-surgical complications. Here we show how G49, an oxyntomodulin (OXM) analog and dual glucagon/glucagon-like peptide-1 receptor (GCGR/GLP-1R) agonist, trigger...
Alternative Titles
Full title
The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk
Authors, Artists and Contributors
Author / Creator
Ruiz, Laura
Folgueira, Cintia
Rada, Patricia
Gomez-Santos, Beatriz
Solas, Maite
Hitos, Ana B.
Field, Joss
Francisco, Vera
Escalona-Garrido, Carmen
Zagmutt, Sebastián
Calderon-Dominguez, María
Mera, Paula
Garcia-Martinez, Irma
Maymó-Masip, Elsa
Grajales, Diana
Alen, Rosa
Mora, Alfonso
Sáinz, Neira
Vides-Urrestarazu, Irene
Vilarrasa, Nuria
Arbones-Mainar, José M.
Zaragoza, Carlos
Moreno-Aliaga, María J.
Aspichueta, Patricia
Fernández-Veledo, Sonia
Vendrell, Joan
Serra, Dolors
Herrero, Laura
Schreiber, Renate
Zechner, Rudolf
Sabio, Guadalupe
Hornigold, David
Rondinone, Cristina M.
Jermutus, Lutz
Grimsby, Joseph
Valverde, Ángela M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6e46df4151b04affa21678e1243d004d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6e46df4151b04affa21678e1243d004d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-54080-w
