A conformational fingerprint for amyloidogenic light chains
A conformational fingerprint for amyloidogenic light chains
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Publisher
England: eLife Sciences Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Sciences Publications, Ltd
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Scope and Contents
Contents
Both immunoglobulin light-chain (LC) amyloidosis (AL) and multiple myeloma (MM) share the overproduction of a clonal LC. However, while LCs in MM remain soluble in circulation, AL LCs misfold into toxic-soluble species and amyloid fibrils that accumulate in organs, leading to distinct clinical manifestations. The significant sequence variability of...
Alternative Titles
Full title
A conformational fingerprint for amyloidogenic light chains
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TN_cdi_doaj_primary_oai_doaj_org_article_6e5b96d6733d4a1cac547bfbf38fd873
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6e5b96d6733d4a1cac547bfbf38fd873
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.102002
