Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells
Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Methylglyoxal (MGO), a precursor of advanced glycation end products (AGEs), is regarded as a pivotal mediator of vascular damage in patients with diabetes. We have previously reported that MGO induces transcriptional changes compatible with p53 activation in cultured human endothelial cells. To further substantiate this finding and to explore the u...
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Methylglyoxal induces p53 activation and inhibits mTORC1 in human umbilical vein endothelial cells
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TN_cdi_doaj_primary_oai_doaj_org_article_6ec653575d044273a6fd2d3553d72164
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6ec653575d044273a6fd2d3553d72164
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-87561-9
