Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance...
Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Intestinal epithelial cells derived from human pluripotent stem cells (hPSCs) are generally maintained and cultured as organoids in vitro because they do not exhibit adhesion when cultured. However, the three-dimensional structure of organoids makes their use in regenerative medicine and drug discovery difficult. Mesenchymal stromal cells are found...
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Full title
Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_6ec93bb9c61e473cb9c9023b394985d0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6ec93bb9c61e473cb9c9023b394985d0
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ISSN
1757-6512
E-ISSN
1757-6512
DOI
10.1186/s13287-023-03629-5
