Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System...
Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis
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Author / Creator
Zhou, Biao , Gao, Yamin , Zhao, Heyu , Liu, Banghui , Zhang, Han , Fang, Cuiting , Yuan, Hang , Wang, Jingjing , Li, Zimu , Zhao, Yi , Huang, Xiaodong , Wang, Xiyue , Oliveira, A. Sofia. F. , Spencer, James , Mulholland, Adrian J. , Burston, Steven G. , Hu, Jinxing , Su, Ning , Chen, Xinwen , He, Jun , Zhang, Tianyu and Xiong, Xiaoli
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The caseinolytic protease (Clp) system has recently emerged as a promising anti-tuberculosis target. The anti-cancer drug bortezomib exhibits potent anti-mycobacterial activity and binds to
Mycobacterium tuberculosis
(
Mtb
) Clp protease complexes. We determine cryo-EM structures of
Mtb
ClpP1P2, ClpC1P1P2 and ClpXP1P2 complexes bo...
Alternative Titles
Full title
Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis
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Author / Creator
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TN_cdi_doaj_primary_oai_doaj_org_article_6eec1a8103ce4ca0a63fb7a0043cadc0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6eec1a8103ce4ca0a63fb7a0043cadc0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58410-4
