Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression o...
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
About this item
Full title
Author / Creator
Meçe, Odeta , Houbaert, Diede , Sassano, Maria-Livia , Durré, Tania , Maes, Hannelore , Schaaf, Marco , More, Sanket , Ganne, Maarten , García-Caballero, Melissa , Borri, Mila , Verhoeven, Jelle , Agrawal, Madhur , Jacobs, Kathryn , Bergers, Gabriele , Blacher, Silvia , Ghesquière, Bart , Dewerchin, Mieke , Swinnen, Johan V. , Vinckier, Stefan , Soengas, María S. , Carmeliet, Peter , Noël, Agnès and Agostinis, Patrizia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs responses to VEGF-C and injury-driven corneal lymphangiogenesis. Autophagy loss in LEC compromises the expression of main effectors...
Alternative Titles
Full title
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis
Authors, Artists and Contributors
Author / Creator
Houbaert, Diede
Sassano, Maria-Livia
Durré, Tania
Maes, Hannelore
Schaaf, Marco
More, Sanket
Ganne, Maarten
García-Caballero, Melissa
Borri, Mila
Verhoeven, Jelle
Agrawal, Madhur
Jacobs, Kathryn
Bergers, Gabriele
Blacher, Silvia
Ghesquière, Bart
Dewerchin, Mieke
Swinnen, Johan V.
Vinckier, Stefan
Soengas, María S.
Carmeliet, Peter
Noël, Agnès
Agostinis, Patrizia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6f053768112c4a3e957fc921d9943221
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6f053768112c4a3e957fc921d9943221
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-30490-6
