Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered inter...
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
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Author / Creator
Argonne National Laboratory (ANL), Argonne, IL (United States) , Lama, Lodoe , Adura, Carolina , Xie, Wei , Tomita, Daisuke , Kamei, Taku , Kuryavyi, Vitaly , Gogakos, Tasos , Steinberg, Joshua I. , Miller, Michael , Ramos-Espiritu, Lavoisier , Asano, Yasutomi , Hashizume, Shogo , Aida, Jumpei , Imaeda, Toshihiro , Okamoto, Rei , Jennings, Andy J. , Michino, Mayako , Kuroita, Takanobu , Stamford, Andrew , Gao, Pu , Meinke, Peter , Glickman, J. Fraser , Patel, Dinshaw J. and Tuschl, Thomas
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Cyclic GMP-AMP synthase (cGAS) is the primary sensor for aberrant intracellular dsDNA producing the cyclic dinucleotide cGAMP, a second messenger initiating cytokine production in subsets of myeloid lineage cell types. Therefore, inhibition of the enzyme cGAS may act anti-inflammatory. Here we report the discovery of human-cGAS-specific small-molec...
Alternative Titles
Full title
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
Authors, Artists and Contributors
Author / Creator
Lama, Lodoe
Adura, Carolina
Xie, Wei
Tomita, Daisuke
Kamei, Taku
Kuryavyi, Vitaly
Gogakos, Tasos
Steinberg, Joshua I.
Miller, Michael
Ramos-Espiritu, Lavoisier
Asano, Yasutomi
Hashizume, Shogo
Aida, Jumpei
Imaeda, Toshihiro
Okamoto, Rei
Jennings, Andy J.
Michino, Mayako
Kuroita, Takanobu
Stamford, Andrew
Gao, Pu
Meinke, Peter
Glickman, J. Fraser
Patel, Dinshaw J.
Tuschl, Thomas
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_6f06ae155ca2436dab39b0d693daf384
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6f06ae155ca2436dab39b0d693daf384
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08620-4
