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Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6fcd942ce65e46ffbe8e7141748f29e6

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

Publication information

Publisher

England: BioMed Central Ltd

More information

Scope and Contents

Contents

The insulin-like growth factor 2 (IGF2) is overexpressed in 90% of adrenocortical carcinomas (ACC) and promotes cell proliferation via IGF1R and isoform A of insulin receptor (IRA). However, IGF2 role in ACC tumourigenesis has not been completely understood yet, and the contribution of IGF1R and IRA in mediating ACC cell growth has been poorly expl...

Alternative Titles

Full title

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_6fcd942ce65e46ffbe8e7141748f29e6

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6fcd942ce65e46ffbe8e7141748f29e6

Other Identifiers

ISSN

1478-811X

E-ISSN

1478-811X

DOI

10.1186/s12964-025-02115-0

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