Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells
Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells
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Adams, Melissa T , Dwulet, JaeAnn M , Briggs, Jennifer K , Reissaus, Christopher A , Jin, Erli , Szulczewski, Joseph M , Lyman, Melissa R , Sdao, Sophia M , Kravets, Vira , Nimkulrat, Sutichot D , Ponik, Suzanne M , Merrins, Matthew J , Mirmira, Raghavendra G , Linnemann, Amelia K , Benninger, Richard KP and Blum, Barak
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Cambridge: eLife Sciences Publications Ltd
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English
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Cambridge: eLife Sciences Publications Ltd
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The spatial architecture of the islets of Langerhans is hypothesized to facilitate synchronized insulin secretion among β cells, yet testing this in vivo in the intact pancreas is challenging. Robo βKO mice, in which the genes Robo1 and Robo2 are deleted selectively in β cells, provide a unique model of altered islet spatial architecture without lo...
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Full title
Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells
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TN_cdi_doaj_primary_oai_doaj_org_article_6ffc13e7f9f7467bb80f8e6003960f0d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_6ffc13e7f9f7467bb80f8e6003960f0d
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.61308
