TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only su...
TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer's disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. In AD mouse models, knockout (KO) of TREM2 impairs microglial clustering around amyloid and prevents microglial activation....
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TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages
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TN_cdi_doaj_primary_oai_doaj_org_article_7003790f6cc94c199bdb2b9d9a1caf4d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7003790f6cc94c199bdb2b9d9a1caf4d
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ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-020-00709-z
