mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectiv...
mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
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Author / Creator
Pagani, Marco , Barsotti, Noemi , Bertero, Alice , Trakoshis, Stavros , Ulysse, Laura , Locarno, Andrea , Miseviciute, Ieva , De Felice, Alessia , Canella, Carola , Supekar, Kaustubh , Galbusera, Alberto , Menon, Vinod , Tonini, Raffaella , Deco, Gustavo , Lombardo, Michael V. , Pasqualetti, Massimo and Gozzi, Alessandro
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Postmortem studies have revealed increased density of excitatory synapses in the brains of individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR-dependent synaptic pruning. ASD is also characterized by atypical macroscale functional connectivity as measured with resting-state fMRI (rsfMRI). These observations raise...
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Full title
mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_70359fada3144b60afebb40b9d37244f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_70359fada3144b60afebb40b9d37244f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26131-z
