Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase...
Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Transglutaminase 3 (TG3), the autoantigen of dermatitis herpetiformis (DH), is a calcium dependent enzyme that targets glutamine residues in polypeptides for either transamidation or deamidation modifications. To become catalytically active TG3 requires proteolytic cleavage between the core domain and two C-terminal β-barrels (C1C2). Here, we repor...
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Full title
Autoantibody binding and unique enzyme-substrate intermediate conformation of human transglutaminase 3
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TN_cdi_doaj_primary_oai_doaj_org_article_7086bf68c62a49909723f5d535c05f49
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7086bf68c62a49909723f5d535c05f49
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42004-z
