PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
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England: BioMed Central Ltd
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English
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Publisher
England: BioMed Central Ltd
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Polygenic risk scores (PRSs) have wide applications in human genetics research, but often include tuning parameters which are difficult to optimize in practice due to limited access to individual-level data. Here, we introduce PUMAS, a novel method to fine-tune PRS models using summary statistics from genome-wide association studies (GWASs). Throug...
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PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
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TN_cdi_doaj_primary_oai_doaj_org_article_70c19ff70b3a44aabaf63eef0e36c681
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_70c19ff70b3a44aabaf63eef0e36c681
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-021-02479-9
