Identification of a novel and high affinity MIF inhibitor via structure-based pharmacophore modellin...
Identification of a novel and high affinity MIF inhibitor via structure-based pharmacophore modelling, molecular docking, molecular dynamics simulations, and biological evaluation
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Author / Creator
Zhu, Shang , Yang, Shudan , Chen, Yao , Niu, Miao-Miao , Wang, Jun , Li, Jindong and Pu, Xuehua
Publisher
England: Taylor & Francis
Journal title
Language
English
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Publication information
Publisher
England: Taylor & Francis
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Scope and Contents
Contents
Macrophage migration inhibitory factor (MIF) plays a crucial role in disrupting immune homeostasis and was overexpressed in immune cells. The inhibitors of MIF inhibit the release of inflammatory factors to treat sepsis. Herein, a series of compounds (termed as Hits 1-6) were discovered based on pharmacophore modelling, molecular docking, and inter...
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Full title
Identification of a novel and high affinity MIF inhibitor via structure-based pharmacophore modelling, molecular docking, molecular dynamics simulations, and biological evaluation
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_714b5d19d1314c1c9a56a7dfd86eb9d3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_714b5d19d1314c1c9a56a7dfd86eb9d3
Other Identifiers
ISSN
1475-6366,1475-6374
E-ISSN
1475-6374
DOI
10.1080/14756366.2025.2501378
