Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schiz...
Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Elevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length Tropomyosin kinase B receptor (TrkB
TK+
). The truncated BDNF receptor (TrkB
TK-
) and the...
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Full title
Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation
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TN_cdi_doaj_primary_oai_doaj_org_article_720a44dabf9e4bf6b213f67e5b5a5241
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_720a44dabf9e4bf6b213f67e5b5a5241
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ISSN
2158-3188
E-ISSN
2158-3188
DOI
10.1038/s41398-025-03359-7
