Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
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Author / Creator
Pacific Northwest National Lab. (PNNL), Richland, WA (United States) , Chiao, Ying Ann , Zhang, Huiliang , Sweetwyne, Mariya , Whitson, Jeremy , Ting, Ying Sonia , Basisty, Nathan , Pino, Lindsay K , Quarles, Ellen , Nguyen, Ngoc-Han , Campbell, Matthew D , Zhang, Tong , Gaffrey, Matthew J , Merrihew, Gennifer , Wang, Lu , Yue, Yongping , Duan, Dongsheng , Granzier, Henk L , Szeto, Hazel H , Qian, Wei-Jun , Marcinek, David , MacCoss, Michael J and Rabinovitch, Peter
Publisher
England: eLife Sciences Publications Ltd
Journal title
Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Diastolic dysfunction is a prominent feature of cardiac aging in both mice and humans. We show here that 8-week treatment of old mice with the mitochondrial targeted peptide SS-31 (elamipretide) can substantially reverse this deficit. SS-31 normalized the increase in proton leak and reduced mitochondrial ROS in cardiomyocytes from old mice, accompa...
Alternative Titles
Full title
Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Authors, Artists and Contributors
Author / Creator
Chiao, Ying Ann
Zhang, Huiliang
Sweetwyne, Mariya
Whitson, Jeremy
Ting, Ying Sonia
Basisty, Nathan
Pino, Lindsay K
Quarles, Ellen
Nguyen, Ngoc-Han
Campbell, Matthew D
Zhang, Tong
Gaffrey, Matthew J
Merrihew, Gennifer
Wang, Lu
Yue, Yongping
Duan, Dongsheng
Granzier, Henk L
Szeto, Hazel H
Qian, Wei-Jun
Marcinek, David
MacCoss, Michael J
Rabinovitch, Peter
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_720f135c89f7440e948956a2b4dd4a5d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_720f135c89f7440e948956a2b4dd4a5d
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.55513
