Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic c...
Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis
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England: BioMed Central Ltd
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English
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Publisher
England: BioMed Central Ltd
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Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted therapies have been developed and shown anticancer efficacy in preclinical settings, none of them has been approved yet.
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Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis
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TN_cdi_doaj_primary_oai_doaj_org_article_724af697d9fd407d8d9e9c49e0e972b4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_724af697d9fd407d8d9e9c49e0e972b4
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-022-01538-4
