APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across m...
APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The APOBEC3 (apolipoprotein B mRNA editing enzyme catalytic polypeptide 3) family of cytidine deaminases is responsible for two mutational signatures (SBS2 and SBS13) found in cancer genomes. APOBEC3 enzymes are activated in response to viral infection, and have been associated with increased mutation burden and TP53 mutation. In addition to this,...
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Full title
APOBEC3 mutational signatures are associated with extensive and diverse genomic instability across multiple tumour types
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TN_cdi_doaj_primary_oai_doaj_org_article_726228cf9f9642149bcbd187a12eda3a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_726228cf9f9642149bcbd187a12eda3a
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ISSN
1741-7007
E-ISSN
1741-7007
DOI
10.1186/s12915-022-01316-0
