Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lyso...
Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Defective lysosomal acidification contributes to virtually all lysosomal storage disorders (LSDs) and to common neurodegenerative diseases like Alzheimer’s and Parkinson’s. Despite its fundamental importance, the mechanism(s) underlying this defect remains unclear. The v-ATPase, a multisubunit protein complex composed of cytosolic V1-sector and lys...
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Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model
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TN_cdi_doaj_primary_oai_doaj_org_article_728ace11a95a4edda7a3da8550cb2ff6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_728ace11a95a4edda7a3da8550cb2ff6
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2041-1723
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2041-1723
DOI
10.1038/ncomms14612
