Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Molecular mechanisms associated with human germ cell aplasia in infertile men remain undefined. Here we perform single-cell transcriptome profiling to highlight differentially expressed genes and pathways in each somatic cell type in testes of men with idiopathic germ cell aplasia. We identify immaturity of Leydig cells, chronic tissue inflammation...
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Full title
Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia
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TN_cdi_doaj_primary_oai_doaj_org_article_72d44dea6e06424a96786fa8a4b23932
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_72d44dea6e06424a96786fa8a4b23932
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25544-0
