Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL...
Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis
About this item
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Author / Creator
Huang, Dane , Zhao, Chao , Li, Ruyue , Chen, Bingyi , Zhang, Yuting , Sun, Zhejun , Wei, Junkang , Zhou, Huihao , Gu, Qiong and Xu, Jun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
One of the major challenges for discovering protein-protein interaction inhibitors is identifying selective and druggable binding sites at the protein surface. Here, we report an approach to identify a small molecular binding site to selectively inhibit the interaction of soluble RANKL and RANK for designing anti-osteoporosis drugs without undesira...
Alternative Titles
Full title
Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_72ed5536113e4557af499911ac1cabd6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_72ed5536113e4557af499911ac1cabd6
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-33006-4
