Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
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Author / Creator
Zhou, Chen , Yan, Ling , Zhang, Wen-hui and Liu, Zhu
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The C-terminus of α-tubulin undergoes a detyrosination/tyrosination cycle and dysregulation of this cycle is associated with cancer and other diseases. The molecular mechanisms of tubulin tyrosination are well studied, however it has remained unknown how tyrosine is cleaved from the tubulin tail. Here, we report the crystal structure of the long-so...
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Full title
Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer
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TN_cdi_doaj_primary_oai_doaj_org_article_73149a2dc2634b788e4b85463c6af74a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_73149a2dc2634b788e4b85463c6af74a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11277-8
