Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
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Author / Creator
Glez-Vaz, Javier , Azpilikueta, Arantza , Olivera, Irene , Cirella, Assunta , Teijeira, Alvaro , Ochoa, Maria C , Alvarez, Maite , Eguren-Santamaria, Iñaki , Luri-Rey, Carlos , Rodriguez-Ruiz, Maria E , Nie, Xinxin , Chen, Lieping , Guedan, Sonia , Sanmamed, Miguel F , Luis Perez Gracia, Jose and Melero, Ignacio
Publisher
England: BMJ Publishing Group Ltd
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Language
English
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Publisher
England: BMJ Publishing Group Ltd
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Contents
BackgroundOn the basis of efficacy in mouse tumor models, multiple CD137 (4-1BB) agonist agents are being preclinically and clinically developed. The costimulatory molecule CD137 is inducibly expressed as a transmembrane or as a soluble protein (sCD137). Moreover, the CD137 cytoplasmic signaling domain is a key part in approved chimeric antigen rec...
Alternative Titles
Full title
Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
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TN_cdi_doaj_primary_oai_doaj_org_article_73397a239a8744e29c59d4accc19c284
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_73397a239a8744e29c59d4accc19c284
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-003532
