Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic canc...
Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis
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Author / Creator
Dai, Weiqi , Wu, Xiaoli , Li, Jingjing , Tang, Wenxi , Wang, Ying , Xu, Wenqiang , Han, Dengyu , Xu, Xiaorong and Xu, Xuanfu
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Hedgehog-Gli1 signaling induces development of two common neurological features seen in pancreatic ductal adenocarcinoma (PDAC): peripheral neural invasion (PNI) and peripheral neural remodeling (PNR). However, the underlying molecular mechanisms in cancer cells and nerves within Gli1-derived PNR have not previously been comprehensively analyzed.
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Full title
Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis
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TN_cdi_doaj_primary_oai_doaj_org_article_7340298fea1e4cf6b46dc3d2c8660a44
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7340298fea1e4cf6b46dc3d2c8660a44
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-023-02894-9
