The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGF...
The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in angiogenesis. The P-type ATPase transporter ATP7A regulates copper homeostasis, and its role in VEGFR2 signaling and angiogenesis is entirely unknown. Here, we describe the unexpected crosstalk between the Copper transporter ATP7A, autophagy, and VEGFR2 degradation. The...
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Full title
The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2
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TN_cdi_doaj_primary_oai_doaj_org_article_7349411310e2453bb951aceb39ac7122
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7349411310e2453bb951aceb39ac7122
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23408-1
