5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC patients. Here, we demonstrate that p53 promotes
WNT3
transcription, leading to activation of the WNT/β-catenin pathway in
A...
Alternative Titles
Full title
5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
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TN_cdi_doaj_primary_oai_doaj_org_article_734b08cd776a44bf9b6930273cd2ce5d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_734b08cd776a44bf9b6930273cd2ce5d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19173-2
