Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confe...
Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
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Author / Creator
Chen, Ye , Xu, Liang , Mayakonda, Anand , Huang, Mo-Li , Kanojia, Deepika , Tan, Tuan Zea , Dakle, Pushkar , Lin, Ruby Yu-Tong , Ke, Xin-Yu , Said, Jonathan W. , Chen, Jianxiang , Gery, Sigal , Ding, Ling-Wen , Jiang, Yan-Yi , Pang, Angela , Puhaindran, Mark Edward , Goh, Boon Cher and Koeffler, H. Phillip
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Liposarcomas (LPSs) are a group of malignant mesenchymal tumors showing adipocytic differentiation. Here, to gain insight into the enhancer dysregulation and transcriptional addiction in this disease, we chart super-enhancer structures in both LPS tissues and cell lines. We identify a bromodomain and extraterminal (BET) protein-cooperated FUS-DDIT3...
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Full title
Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma
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TN_cdi_doaj_primary_oai_doaj_org_article_737f0325add94122b8c3c1a96fabd32f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_737f0325add94122b8c3c1a96fabd32f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09257-z
