Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations
Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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DNA methyltransferase DNMT3B plays an essential role in establishment of DNA methylation during embryogenesis. Mutations of DNMT3B are associated with human diseases, notably the immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome. How ICF mutations affect DNMT3B activity is not fully understood. Here we report the homo-ol...
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Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations
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TN_cdi_doaj_primary_oai_doaj_org_article_73b70bc5fb234b0d9d8d9c3f4ec9a089
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_73b70bc5fb234b0d9d8d9c3f4ec9a089
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31933-w
