Conserved allosteric inhibition mechanism in SLC1 transporters
Conserved allosteric inhibition mechanism in SLC1 transporters
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England: eLife Science Publications, Ltd
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Language
English
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England: eLife Science Publications, Ltd
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Contents
Excitatory amino acid transporter 1 (EAAT1) is a glutamate transporter belonging to the SLC1 family of solute carriers. It plays a key role in the regulation of the extracellular glutamate concentration in the mammalian brain. The structure of EAAT1 was determined in complex with UCPH-101, apotent, non-competitive inhibitor of EAAT1. Alanine serine...
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Full title
Conserved allosteric inhibition mechanism in SLC1 transporters
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TN_cdi_doaj_primary_oai_doaj_org_article_73cb33321df14974abd825f88d0a87d3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_73cb33321df14974abd825f88d0a87d3
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.83464
