CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell a...
CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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While effective in specific settings, adoptive chimeric antigen receptor (CAR) T cell therapy for cancer requires further improvement and optimization. Our previous results show that CD40L-overexpressing CAR T cells mobilize endogenous immune effectors, resulting in improved antitumor immunity. However, the cell populations required for this protec...
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CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function
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TN_cdi_doaj_primary_oai_doaj_org_article_73e25f98128942e1a7488cf2c4e6a8e9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_73e25f98128942e1a7488cf2c4e6a8e9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19833-3
