Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation
Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects of RNA metabolism including translation initiation and the assembly of stress granules (SGs). Recent genomic studies have reported recurrent DDX3X mutations in numerous tumors including medulloblastoma (MB), but the physiological impact of these mutations is poorly unders...
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Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation
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TN_cdi_doaj_primary_oai_doaj_org_article_740bec2ec2be4c35aafbd83048a74f4c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_740bec2ec2be4c35aafbd83048a74f4c
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep25996
