Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic...
Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mechanism-based glycoside hydrolase inhibitors are carbohydrate analogs that mimic the natural substrate’s structure. Their covalent bond formation with the glycoside hydrolase makes these compounds excellent tools for chemical biology and potential drug candidates. Here we report the synthesis of cyclohexene-based α-galactopyranoside mimics and th...
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Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level
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TN_cdi_doaj_primary_oai_doaj_org_article_744697e101804594badef9eae41b0671
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_744697e101804594badef9eae41b0671
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05702-7
