Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolut...
Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Nonstop extension mutations, a.k.a. stop-lost or stop-loss mutations, convert a stop codon into a sense codon resulting in translation into the 3’ untranslated region until the next in-frame stop codon, thereby extending the C-terminus of a protein. In cancer, only nonstop mutations in SMAD4 have been functionally characterized, while the impact of...
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Suppressive cancer nonstop extension mutations increase C-terminal hydrophobicity and disrupt evolutionarily conserved amino acid patterns
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TN_cdi_doaj_primary_oai_doaj_org_article_745ed8d59e844c9eb147857b617e465f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_745ed8d59e844c9eb147857b617e465f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-52779-4
