Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
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Burger, Wessel A. C. , Pham, Vi , Vuckovic, Ziva , Powers, Alexander S. , Mobbs, Jesse I. , Laloudakis, Yianni , Glukhova, Alisa , Wootten, Denise , Tobin, Andrew B. , Sexton, Patrick M. , Paul, Steven M. , Felder, Christian C. , Danev, Radostin , Dror, Ron O. , Christopoulos, Arthur , Valant, Celine and Thal, David M.
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
The M
4
muscarinic acetylcholine receptor (M
4
mAChR) has emerged as a drug target of high therapeutic interest due to its expression in regions of the brain involved in the regulation of psychosis, cognition, and addiction. The mAChR agonist, xanomeline, has provided significant improvement in the Positive and Negative Symptom Scale (P...
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Full title
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
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TN_cdi_doaj_primary_oai_doaj_org_article_7484d1906038449ebf83ab0a1980953a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7484d1906038449ebf83ab0a1980953a
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41199-5
