Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy
Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy
About this item
Full title
Author / Creator
Borot, Florence , Humbert, Olivier , Ehmsen, Jeffrey T. , Fields, Emily , Kohli, Sajeev , Radtke, Stefan , Swing, Kyle , Pande, Dnyanada , Enstrom, Mark R. , Laszlo, George S. , Mayuranathan, Thiyagaraj , Ali, Abdullah Mahmood , Weiss, Mitchell J. , Yen, Jonathan S. , Newby, Gregory A. , Walter, Roland B. , Liu, David R. , Mukherjee, Siddhartha and Kiem, Hans-Peter
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The selection of genetically engineered immune or hematopoietic cells in vivo after gene editing remains a clinical problem and requires a method to spare on-target toxicity to normal cells. Here, we develop a base editing approach exploiting a naturally occurring
CD33
single nucleotide polymorphism leading to removal of full-length CD33 surf...
Alternative Titles
Full title
Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy
Authors, Artists and Contributors
Author / Creator
Humbert, Olivier
Ehmsen, Jeffrey T.
Fields, Emily
Kohli, Sajeev
Radtke, Stefan
Swing, Kyle
Pande, Dnyanada
Enstrom, Mark R.
Laszlo, George S.
Mayuranathan, Thiyagaraj
Ali, Abdullah Mahmood
Weiss, Mitchell J.
Yen, Jonathan S.
Newby, Gregory A.
Walter, Roland B.
Liu, David R.
Mukherjee, Siddhartha
Kiem, Hans-Peter
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_74a398aa03a04fae953c7a4fb19da916
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_74a398aa03a04fae953c7a4fb19da916
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-59713-2
