The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of...
The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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DUSP22 is a dual-specificity phosphatase that inhibits T cell activation by inactivating the kinase Lck. Here we show that the E3 ubiquitin ligase UBR2 is a positive upstream regulator of Lck during T-cell activation. DUSP22 dephosphorylates UBR2 at specific Serine residues, leading to ubiquitin-mediated UBR2 degradation. UBR2 is also modified by t...
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The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling
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TN_cdi_doaj_primary_oai_doaj_org_article_74ada20324de4b6ca3ec165d10c91490
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_74ada20324de4b6ca3ec165d10c91490
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-44843-w
