Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry
Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Gasdermin D forms large, ~21 nm diameter pores in the plasma membrane to drive the cell death program pyroptosis. These pores are thought to be permanently open, and the resultant osmotic imbalance is thought to be highly damaging. Yet some cells mitigate and survive pore formation, suggesting an undiscovered layer of regulation over the function o...
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Full title
Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry
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TN_cdi_doaj_primary_oai_doaj_org_article_74ba8d66e6d24b648cd298d1979af553
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_74ba8d66e6d24b648cd298d1979af553
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27692-9
