Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrat...
Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The human coronavirus HKU1 uses both sialoglycoconjugates and the protein transmembrane serine protease 2 (TMPRSS2) as receptors. Carbohydrate binding leads to the spike protein
up
conformation required for TMPRSS2 binding, an outcome suggesting a distinct mechanism for driving fusion of the viral and host cell membranes. Nevertheless, the co...
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Full title
Human coronavirus HKU1 spike structures reveal the basis for sialoglycan specificity and carbohydrate-promoted conformational changes
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TN_cdi_doaj_primary_oai_doaj_org_article_74dd0ad15fd142478197c9fb4910ca55
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_74dd0ad15fd142478197c9fb4910ca55
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-59137-y
