Non-β-Lactam Allosteric Inhibitors Target Methicillin-Resistant Staphylococcus aureus: An In Silico...
Non-β-Lactam Allosteric Inhibitors Target Methicillin-Resistant Staphylococcus aureus: An In Silico Drug Discovery Study
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Publisher
Basel: MDPI AG
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Language
English
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Basel: MDPI AG
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Contents
Penicillin-binding proteins (PBPs) catalyze the final stages for peptidoglycan cell-wall bio-synthesis. Mutations in the PBP2a subunit can attenuate β-lactam antibiotic activity, resulting in unimpeded cell-wall formation and methicillin-resistant Staphylococcus aureus (MRSA). A double mutation in PBP2a (i.e., N146K and E150K) is resistant to β-lac...
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Full title
Non-β-Lactam Allosteric Inhibitors Target Methicillin-Resistant Staphylococcus aureus: An In Silico Drug Discovery Study
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TN_cdi_doaj_primary_oai_doaj_org_article_74fc6dc8aba64b78bd912c4a5f39d81a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_74fc6dc8aba64b78bd912c4a5f39d81a
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ISSN
2079-6382
E-ISSN
2079-6382
DOI
10.3390/antibiotics10080934
