Engineered FGF19ΔKLB protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2...
Engineered FGF19ΔKLB protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2-/- mice model
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Author / Creator
Shi, Lu , Zhao, Tiantian , Huang, Lei , Pan, Xiaomin , Wu, Tianzhen , Feng, Xin , Chen, Taoli , Wu, Jiamin and Niu, Jianlou
Publisher
London: BioMed Central
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Language
English
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Publisher
London: BioMed Central
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BackgroundThe major safety concern of the clinical application of wild type FGF19 (FGF19WT) emerges given that its extended treatment causes hepatocellular carcinoma. Therefore, we previously generated a safer FGF19 variant - FGF19ΔKLB, which have same effects on glycemic control and bile acid production but much less mitogenic activity. However, i...
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Full title
Engineered FGF19ΔKLB protects against intrahepatic cholestatic liver injury in ANIT-induced and Mdr2-/- mice model
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TN_cdi_doaj_primary_oai_doaj_org_article_752e3deb8380431b907f6acfa6bbc775
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_752e3deb8380431b907f6acfa6bbc775
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ISSN
1472-6750
E-ISSN
1472-6750
DOI
10.1186/s12896-023-00810-9
