Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci
Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus is associated with mecA-an acquired gene encoding an extra penicillin-binding protein (PBP2a) with low affinity to virtually all β-lactams. The introduction of mecA into the S. aureus chromosome has led to the emergence of methicillin-resistant S. aureu...
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Full title
Evidence for the evolutionary steps leading to mecA-mediated β-lactam resistance in staphylococci
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TN_cdi_doaj_primary_oai_doaj_org_article_7531cc90ac664bd3be298f8caa8c2183
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7531cc90ac664bd3be298f8caa8c2183
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1006674
