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Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant ta...

Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant ta...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7542fd4f0b3143c8a94362ae7f8f1328

Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice

About this item

Full title

Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2020-08, Vol.10 (1), p.13845-13845, Article 13845

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Antibodies have been explored extensively as a potential therapeutic for Alzheimer’s disease, where amyloid-β (Aβ) peptides and the tau protein deposit in patient brains. While the major focus of antibody-based therapy development was on Aβ, arguably with limited success in clinical trials, targeting tau has become an emerging strategy, possibly ex...

Alternative Titles

Full title

Contribution of endogenous antibodies to learning deficits and astrocytosis in human P301S mutant tau transgenic mice

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_7542fd4f0b3143c8a94362ae7f8f1328

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_7542fd4f0b3143c8a94362ae7f8f1328

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-020-70845-x

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